Photo: Boris Streubel / Getty Images Sport / Getty Images
The Indianapolis Colts should come out on top in their matchup versus the Kansas City Chiefs at 1 p.m. ET on Sunday, Nov. 23, based on our computer projections. If you're looking for more predictions on the final score, spread, and point total, we list those numbers below.
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Chiefs vs. Colts Game Info and TV Channel
- When: Sunday, November 23, 2025 at 1 p.m. ET
- Where: GEHA Field at Arrowhead Stadium in Kansas City, Missouri
- TV: CBS
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
- Live Stream: Watch this game on Paramount+ (Regional restrictions may apply)
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Listen to the game on 96.5 The Fan
Chiefs vs. Colts Odds and Betting Info
- Spread favorite: Chiefs (-3.5)
- Moneyline: Chiefs (-184), Colts (+153)
- Total: 49.5 points
Chiefs vs. Colts Prediction
- Pick ATS: Colts (+3.5)
- Pick OU: Under (49.5)
Prediction:
Colts 25 - Chiefs 24
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Chiefs vs. Colts Betting Insights
- The Chiefs have covered five times in 10 matchups with a spread this season.
- The Colts have put together a 6-4-0 record against the spread this season.
- Kansas City has an ATS record of 3-2 when playing as at least 3.5-point favorites this season.
- Indianapolis has not covered the spread this year (0-1 ATS) when playing as at least 3.5-point underdogs.
- The Chiefs and their opponent have combined to hit the over three out of 10 times this season.
- So far this year, six out of the Colts' 10 games with a set over/under have gone over the point total.
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