Big 12 foes match up when the Iowa State Cyclones (7-4) and the Oklahoma State Cowboys (1-10) square off on Saturday, November 29, 2025 at Boone Pickens Stadium.
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Iowa State vs. Oklahoma State Matchup Info
- Game date: Saturday, November 29, 2025
- Game time: 12 p.m. ET
- Location: Stillwater, Oklahoma
- Venue: Boone Pickens Stadium
- TV channel: ESPNU
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Iowa State vs. Oklahoma State Odds and Prediction
- Spread favorite: Cyclones (-13.5)
- Moneyline: Cyclones (-565), Cowboys (+412)
- Total: 46.5 points
- Pick ATS: Iowa State (-13.5)
- Pick OU: Over (46.5)
- Prediction: Iowa State 37, Oklahoma State 12
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Iowa State vs. Oklahoma State Betting Records and Insights
- Iowa State has covered five times in 11 games with a spread this season.
- Oklahoma State has compiled a 4-7-0 record against the spread this season.
- The Cyclones have covered the spread once when favored by 13.5 points or more this season (in two opportunities).
- The Cowboys have covered the spread four times this season (4-5 ATS) when playing as at least 13.5-point underdogs.
- Iowa State games have gone over the point total four out of 11 times this season.
- Oklahoma State and its opponent have combined to go over the point total five out of 11 times this year.