Colts vs. Chiefs Week 2 Predictions, Odds and Stats

Our computer model predicts the Kansas City Chiefs will beat the Indianapolis Colts on Sunday, Sept. 20 at 8:20 p.m. ET. For a complete projection on the game at GEHA Field at Arrowhead Stadium, which includes our prediction on the spread, over/under, and final score, keep reading.

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Colts vs. Chiefs Game Info and TV Channel

• When: Sunday, September 20, 2026 at 8:20 p.m. ET
• Where: GEHA Field at Arrowhead Stadium in Kansas City, Missouri
• TV: NBC/Peacock
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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Listen to the game on 96.5 The Fan

Colts vs. Chiefs Odds and Betting Info

• Spread favorite: Chiefs (-6.5)
• Moneyline: Chiefs (-303), Colts (+244)
• Total: 46.5 points

Colts vs. Chiefs Prediction

• Pick ATS: Colts (+6.5)
• Pick OU: Over (46.5)

Prediction:

Chiefs 27 - Colts 26

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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Colts vs. Chiefs Betting Insights (2025 Stats)

• The Chiefs put together a 6-11-0 ATS record last year.
• The Colts covered nine times in 17 chances against the spread last season.
• Kansas City was favored by 6.5 points or more two times last season, and covered the spread in both.
• Indianapolis covered the spread when playing as at least 6.5-point underdogs in two of two opportunities last year.
• Last season, four of the Chiefs' games hit the over.
• The Colts and their opponent combined to hit the over nine out of 17 times last season.

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